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Metals in Biological Systems  
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PUBLICATIONS
 
28.
Young, C. J., Siemann, S. (2016) Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site. Chem. Commun. 52, 11748-11751. [pdf] Article featured on the cover of ChemComm.
27.
Riopel, R., Siemann, S., Caron, F. (2016) Microbial changes in the fluorescence character of natural organic matter from a wastewater source. J. Water Resource Prot. 8, 873-883. [pdf] OPEN ACCESS
26.
Rotondo, C. M., Marrone, L., Goodfellow, V. J., Ghavami, A., Labbé, G., Spencer, J., Dmitrienko, G. I., Siemann, S. (2015) Arginine-containing peptides as potent inhibitors of VIM-2 metallo-β-lactamase. Biochim. Biophys. Acta 1850, 2228-2238. [pdf]
25.
Ghavami, A., Labbé, G., Brem, J., Goodfellow, V. J., Marrone, L., Tanner, C. A., King, D. T., Lam, M., Strynadka, N. C. J., Pillai, D. R., Siemann, S., Spencer, J., Schofield, C. J., Dmitrienko, G. I. (2015) Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates. Anal. Biochem. 486, 75-77. [pdf]
24.
Lo, S. Y., Säbel, C. E., Mapletoft, J. P., Siemann, S. (2015) Influence of chemical denaturants on the activity, fold and metal status of anthrax lethal factor. Biochem. Biophys. Rep. 1, 68-77. [pdf] OPEN ACCESS
23.
Riopel, R., Caron, F., Siemann, S. (2014) Fluorescence Characterization of Natural Organic Matter at a Northern Ontario Waste Water Treatment Plant. Water Air Soil Pollut. 225, 2126. [pdf]
22.
Lo, S. Y., Säbel, C. E., Webb, M. I., Walsby, C. J., Siemann, S. (2014) High metal substitution tolerance of anthrax lethal factor and characterization of its active copper-substituted analogue. J. Inorg. Biochem. 140, 12-22. [pdf]
21.
Xu, L., Ye, Z., Siemann, S., Gu, Z. (2014) Noncovalent Solubilization of Multi-Walled Carbon Nanotubes in Common Low-Polarity Organic Solvents with Branched Pd–Diimine Polyethylenes: Effects of Polymer Chain Topology, Molecular Weight and Terminal Pyrene Group. Polymer 55, 3120-3129. [pdf]
20.
Caron, F., Siemann, S., Riopel, R. (2014) Characterization of the natural organic matter (NOM) in groundwater contaminated with 60Co and 137Cs using ultrafiltration, solid phase extraction and fluorescence analysis. J. Environ. Radioact. 138, 331-340. [pdf]
19.
Montpellier, L. H., Siemann, S. (2013) Effect of pH on the catalytic function and zinc content of native and immobilized anthrax lethal factor. FEBS Lett. 587, 317-321. [pdf]
18.
Borraro, V., Riopel, R., Caron, F., Siemann, S. (2012) Laboratory study on the impact of pH and salinity on the fluorescence signal of Natural Organic Matter (NOM) relevant to groundwaters from a Canadian Shield sampling site. Water Qual. Res. J. Can. 47, 131-139. [pdf]
17.
Säbel, C. E., Carbone, R., Dabous, J. R., Lo, S. Y., Siemann, S. (2011) Preparation and characterization of cobalt-substituted anthrax lethal factor. Biochem. Biophys. Res. Commun. 416, 106-110. [pdf]
16.
Smith, S. R., Guerra, E., Siemann, S., Shepherd, J. L. (2011) Au dissolution during the anodic response of short-chain alkylthiols with polycrystalline Au electrodes. Electrochim. Acta 56, 8291-8298. [pdf]
15.
Säbel, C. E., St-Denis, S., Neureuther, J. M., Carbone, R., Siemann, S. (2010) Alkaline earth metals are not required for the restoration of the apoform of anthrax lethal factor to its holoenzyme state. Biochem. Biophys. Res. Commun. 403, 209-213. [pdf]
14.
Caron, F., Sharp-King, K., Siemann, S., Smith, D. S. (2010) Fluorescence characterization of the natural organic matter in deep ground waters from the Canadian Shield, Ontario, Canada. J. Radioanal. Nucl. Chem. 286, 699-705. [pdf]
13.
Säbel, C. E., Neureuther, J. M., Siemann, S. (2010) A spectrophotometric method for the determination of zinc, copper, and cobalt ions in metalloproteins using Zincon. Anal. Biochem. 397, 218-226. [pdf]
12.
Säbel, C. E., Shepherd, J. L., Siemann, S. (2009) A direct spectrophotometric method for the simultaneous determination of zinc and cobalt in metalloproteins using 4-(2-pyridylazo)resorcinol. Anal. Biochem. 391, 74-76. [pdf]
11.
Gardonio. D., Siemann, S. (2009) Chelator-facilitated chemical modification of IMP-1 metallo-b-lactamase and its consequences on metal binding. Biochem. Biophys. Res. Commun. 381, 107-111. [pdf]
10.
Siemann, S., Badiei, H. R., Karanassios, V., Viswanatha, T., Dmitrienko, G. I. (2006) 68Zn isotope exchange experiments reveal an unusual kinetic lability of the metal ions in the di-zinc form of IMP-1 metallo-b-lactamase. Chem. Commun., 532-534. [pdf]
9.
Ramsaywak, P. C., Labbé, G., Siemann, S., Dmitrienko, G. I., Guillemette, J. G. (2004) Molecular cloning, expression, purification and characterization of fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis - a novel class II A tetramer. Protein Expr. Purif. 37, 220-228. [pdf]
8.
Siemann, S., Schneider, K., Oley, M., Müller, A. (2003) Characterization of a tungsten-substituted nitrogenase isolated from Rhodobacter capsulatus. Biochemistry 42, 3846-3857. [pdf]
7.
Siemann, S., Clarke, A. J., Viswanatha, T., Dmitrienko, G. I. (2003) Thiols as classical and slow-binding inhibitors of IMP-1 and other binuclear metallo-b-lactamases. Biochemistry 42, 1673-1683. [pdf]
6.
Siemann, S., Evanoff, D., Marrone, L., Clarke, A. J., Viswanatha, T., Dmitrienko, G. I. (2002) N-Arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-b-lactamase. Antimicrob. Agents Chemother. 46, 2450-2457. [pdf]
5.
Siemann, S., Brewer, D., Clarke, A. J., Dmitrienko, G. I., Lajoie, G., Viswanatha, T. (2002) IMP-1 metallo-b-lactamase: effect of chelators and assessment of metal requirement by electrospray mass spectrometry. Biochim. Biophys. Acta 1571, 190-200. [pdf]
4.
Dick, S., Siemann, S., Frey, H. E., Lepock, J. R., Viswanatha, T. (2002) Recombinant lysine:N6-hydroxylase: Effect of cysteine alanine replacements on structural integrity and catalytic competence. Biochim. Biophys. Acta 1594, 219-233. [pdf]
3.
Siemann, S., Schneider, K., Dröttboom, M., Müller, A. (2002) The Fe-only nitrogenase and the Mo nitrogenase from Rhodobacter capsulatus: A comparative study on the redox properties of the metal clusters present in the di-nitrogenase components. Eur. J. Biochem. 269, 1650-1661. [pdf]
2.
Siemann, S., Schneider, K., Behrens, K., Knöchel, A., Klipp, W., Müller, A. (2001) FeMo cofactor biosynthesis in a nifE-mutant of Rhodobacter capsulatus. Eur. J. Biochem. 268, 1940-1952. [pdf]
1.
Marrone, L., Siemann, S., Beecroft, M., Viswanatha, T. (1996) Specificity of lysine:N6-hydroxylase: A hypothesis for a reactive substrate intermediate in the catalytic mechanism. Bioorg. Chem. 24, 401-416. [pdf]